• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News
Sunday, June 8, 2025
  • Login
News Punjab
  • Home
  • Punjab
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Sports
  • Finance/Money
  • Others
    • Agriculture
    • Science
    • Astrology
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
  • Home
  • Punjab
  • India
    • National
    • State News
  • World
  • Business
  • Education
  • Entertainment
  • Lifestyle
    • Health & Fitness
    • Fashion & Beauty
    • Travel
    • Food
    • Photography
  • Tech
    • App News
  • Auto
  • Sports
  • Finance/Money
  • Others
    • Agriculture
    • Science
    • Astrology
    • Press Release
    • Religion
    • Social Work
No Result
View All Result
News Punjab
No Result
View All Result
Home Lifestyle Health & Fitness

Researchers reveal how excess sugar causes fatty liver

by News Punjab Desk
June 18, 2021
in Health & Fitness
Reading Time: 3 mins read
A A
0
Share on FacebookShare on Twitter

New Delhi: In a new study conducted by the researchers at Indian Institute of Technology (IIT), Mandi has conclusively shown that excessive sugar intake leads to a fatty liver. This could offer an incentive for reducing sugar intake to stop non-alcoholic fatty liver disease (NAFLD) in its early stages. The unravelling of the molecular link between sugar and fat accumulation in liver is key to developing therapeutics for the disease, researchers said.

A team of researchers from IIT Mandi, led by Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, has used complementary experimental approaches to establish the underlying biochemical relationship between the consumption of excessive sugar and the development of ‘fatty liver’, medically known as Non-Alcoholic Fatty Liver Disease (NAFLD). This research comes at a time in which the Government of India has included NAFLD in the National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS).

RELATED POSTS

Tvara Superfood Launches India’s First Daily Seed Cycling Blends for Female Hormonal and Chakra Nourishment

Tvara Superfood Launches India’s First Daily Seed Cycling Blends for Female Hormonal and Chakra Nourishment

May 22, 2025
Healing Little Hearts: Dr. Prashant Bobhate Leads Early CHD Detection

Healing Little Hearts: Dr. Prashant Bobhate Leads Early CHD Detection

May 17, 2025

NAFLD is a medical condition in which excess fat deposits in the liver. The disease starts silently, with no overt symptoms for as much as two decades. If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis), and in advanced cases, can even lead to liver cancer. The treatment of advanced stages of NAFLD is difficult.

Dr Prosenjit Mondal said, “The molecular mechanisms that increase hepatic DNL due to overconsumption of sugar have not been clear.” “Our goal was to unravel this mechanistic pathway between excessive sugar consumption and onset and development of fatty liver Through DNL”, he further added.

India is the first country in the world to identify the need for action on NAFLD and with good reason. The prevalence of NAFLD in India is about 9% to 32% of the population, with the state of Kerala alone having a prevalence of 49% and a staggering 60% prevalence among obese school-going children.

One of the causes for NAFLD is the over-consumption of sugar – both table sugar (sucrose) and other forms of carbohydrates. The consumption of excess sugar and carbohydrates causes the liver to convert them into fat in a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver.

Through a complementary experimental approach involving mice models, the IIT Mandi team has shown the hitherto unknown link between the carbohydrate-induced activation of a protein complex called NF-κB and increased DNL.

“Our data indicates that the sugar-mediated shuttling of hepatic NF-κB p65 reduces the levels of another protein, sorcin, which in turn activates liver DNL through a cascading biochemical pathway,” explained the lead scientist.

The research team has shown that drugs that can inhibit NF-κB can prevent sugar-induced hepatic fat accumulation. They have also shown that the knockdown of sorcin reduces the lipid-lowering ability of the NF-κB inhibitor.

This study shows that NAFLD can now be added to the repertoire of diseases that can be treated with drugs that block NF-κB. NF-κB also plays a role in other diseases that involve inflammation, such as cancer, Alzheimer’s disease, atherosclerosis, IBS, stroke, muscle wasting and infections, and scientists around the world are developing therapeutics that can block NF-κB, IIT Mandi Statement said.

This study has been published in the Journal of Biological Chemistry. The research paper has been co-authored by Dr Prosenjit Mondal along with his research scholars, Mr. Vineeth Daniel, Ms. Surbhi Dogra, Ms. Priya Rawat, Mr. Abhinav Choubey from IIT Mandi, in collaboration with Dr Mohan Kamthan and Ms. Aiysha Siddiq Khan from Jamia Hamdard Institute, New Delhi, along with Mr. Sangam Rajak from SGPGI, Lucknow. (India Science Wire)

Tags: Fatty LiverIIT MandiIndian Institute of TechnologyKeywords: Sugar IntakemolecularNAFLDNon-alcoholic fatty liver disease
ShareTweetShareSendSharePinSend
Previous Post

Older adults are at higher risk of social isolation during COVID pandemic: Study

Next Post

Sara Chhipa, 10-year-old, Indian, World Record Holder felicitated by the Consulate General of India in Dubai, UAE

News Punjab Desk

News Punjab Desk

Related Posts

Tvara Superfood Launches India’s First Daily Seed Cycling Blends for Female Hormonal and Chakra Nourishment

Tvara Superfood Launches India’s First Daily Seed Cycling Blends for Female Hormonal and Chakra Nourishment

by News Punjab Desk
May 22, 2025
0

New Delhi, , May 22, 2025 : In a country where conversations around hormonal health and emotional well-being have long...

Healing Little Hearts: Dr. Prashant Bobhate Leads Early CHD Detection

Healing Little Hearts: Dr. Prashant Bobhate Leads Early CHD Detection

by News Punjab Desk
May 17, 2025
0

Every year, approximately 2,00,000 babies in India are born with congenital heart disease (CHD), yet less than 20% receive timely...

Dr Sunita Dube along with 21 Lakh Doctors Supports Tribunal Health law raised in Parliament by MP

Dr Sunita Dube along with 21 Lakh Doctors Supports Tribunal Health law raised in Parliament by MP

by News Punjab Desk
December 12, 2023
0

New Delhi : 12th December 2023: Renowned Radiologist Dr Sunita Dube, a revolutionary doctor has taken a ground-breaking initiative to...

Health check-up camp on 26/11 Martyrs’ Day with PM Modi’s message; Manoj Kumar Jain extended support

Health check-up camp on 26/11 Martyrs’ Day with PM Modi’s message; Manoj Kumar Jain extended support

by News Punjab Desk
November 27, 2023
0

New Delhi : In observance of the 26/11 Martyrs' Day, a mega health check-up camp was organised today, aligning with...

Narayana Health launches their First Ever Brand Campaign ‘Take Care’

Narayana Health launches their First Ever Brand Campaign ‘Take Care’

by News Punjab Desk
September 30, 2023
0

Narayana Health Group – one of India’s leading healthcare providers, committed to delivering exceptional patient care is thrilled to announce...

Next Post

Sara Chhipa, 10-year-old, Indian, World Record Holder felicitated by the Consulate General of India in Dubai, UAE

TTK Prestige Ltd launches a new e-commerce enabled website for its second brand “JUDGE” in India 

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Digital News Giant in the Making: Public Bytes TV on the Rise

Digital News Giant in the Making: Public Bytes TV on the Rise

June 7, 2025
Lotus Derma Botanics Enters the Skincare Arena

Lotus Derma Botanics Enters the Skincare Arena

May 28, 2025
Pahia: A Mohali-Based Startup Empowering Street Vendors with Technology

Pahia: A Mohali-Based Startup Empowering Street Vendors with Technology

May 23, 2025

Categories

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion & Beauty
  • Finance/Money
  • Food
  • Health & Fitness
  • India
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Punjab
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Privacy Policy
  • Follow on Google News

© 2022 News Punjab

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

© 2022 News Punjab

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In